Background:

In a subset of infants exhibiting typical vigabatrin-related magnetic resonance imaging (MRI) changes, the authors observed additional hippocampal signal abnormalities. The authors investigated occurrence and significance of additional signal abnormalities.

Methods:

A retrospective review of infantile spasms patients with typical vigabatrin-related MRI abnormalities was performed. Atypical features included signal changes unilaterally or at previously unreported sites. Comparisons were made between patients with and without atypical features.

Results

In all, 26/55 (47%) exhibited typical vigabatrin-related MRI changes, with additional signal abnormalities in the hippocampi in 6 of 26. On follow-up, evolution of hippocampal signal changes paralleled changes at typical locations in 4 patients. Two patients, clinically well, without follow-up MRI. Patients with and without additional hippocampal signal changes did not differ with respect to clinical factors, including seizure status. One patient had unilateral thalamic/cerebral peduncle signal abnormality along with typical vigabatrin changes.

Conclusions:

Hippocampal changes seen in subset of patients with typical vigabatrin-related changes may be attributable to vigabatrin exposure in the appropriate circumstance.

中文翻译：

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婴儿痉挛患者的海马参与与 Vigabatrin 相关的 MRI 信号异常：一项新发现

背景：

在表现出典型的氨己烯酸相关磁共振成像 (MRI) 变化的婴儿子集中，作者观察到额外的海马信号异常。作者调查了其他信号异常的发生和意义。

方法：

对具有典型氨己烯酸相关 MRI 异常的婴儿痉挛患者进行了回顾性研究。非典型特征包括单方面或以前未报告的站点的信号变化。在具有和不具有非典型特征的患者之间进行了比较。

结果

总体而言，26/55 (47%) 的患者表现出典型的氨己烯酸相关 MRI 变化，26 人中有 6 人在海马中出现额外的信号异常。在随访中，4 名患者的海马信号变化与典型位置的变化平行。两名患者，临床表现良好，未进行MRI随访。有和没有额外海马信号变化的患者在临床因素（包括癫痫发作状态）方面没有差异。一名患者出现单侧丘脑/脑脚信号异常以及典型的氨己烯酸变化。

结论：

在具有典型氨己烯酸相关变化的患者亚组中看到的海马变化可能归因于在适当情况下暴露于氨己烯酸。