Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease,Brain Connectivity

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Resting-State Functional Connectivity Disruption as a Pathological Biomarker in Autosomal Dominant Alzheimer Disease
Brain Connectivity ( IF 2.4 ) Pub Date : 2021-04-13 , DOI: 10.1089/brain.2020.0808
Robert X Smith ₁ , Jeremy F Strain ₁ , Aaron Tanenbaum ₁ , Anne M Fagan _{1,

2} , Jason Hassenstab ₁ , Eric McDade ₁ , Suzanne E Schindler ₁ , Brian A Gordon _{2,

3} , Chengjie Xiong ₄ , Jasmeer Chhatwal ₅ , Clifford Jack ₆ , Celeste Karch _{2,

7} , Sarah Berman ₈ , Jared R Brosch ₉ , James J Lah ₁₀ , Adam M Brickman ₁₁ , David M Cash ₁₂ , Nick C Fox ₁₂ , Neill R Graff-Radford ₁₃ , Johannes Levin ₁₄ , James Noble ₁₁ , David M Holtzman _{1,

2} , Colin L Masters ₁₅ , Martin R Farlow ₉ , Christoph Laske ₁₆ , Peter R Schofield ₁₇ , Daniel S Marcus ₃ , John C Morris _{1,

2} , Tammie L S Benzinger _{2,

3} , Randall J Bateman _{1,

2} , Beau M Ances _{1,

2}

Affiliation

Department of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Hope Center for Neurological Disorders, Knight ADRC, Washington University, St. Louis, Missouri, USA.
Department of Radiology, Washington University in Saint Louis, St. Louis, Missouri, USA.
Department of Biostatistics, Washington University in Saint Louis, St. Louis, Missouri, USA.
Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA.
Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Department of Neurology, Indiana University, Indianapolis, Indiana, USA.
Department of Neurology, Emory University, Atlanta, Georgia, USA.
Department of Neurology, Columbia University, New York, New York, USA.
Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology, University College London, London, United Kingdom.
Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA.
German Center for Neurodegenerative Disease (DZNE) Munich, Munich, Germany.
The Florey Institute, University of Melbourne, Parkvile, Australia.
Eberhard Karls University of Tubingen, Tubingen, Germany.
Neuroscience Research Australia and School of Medical Sciences, The University of New South Wales (UNSW) Sydney, Sydney, Australia.

Aim: Identify a global resting-state functional connectivity (gFC) signature in mutation carriers (MC) from the Dominantly Inherited Alzheimer Network (DIAN). Assess the gFC with regard to amyloid (A), tau (T), and neurodegeneration (N) biomarkers, and estimated years to symptom onset (EYO).

中文翻译：

静息状态功能连接中断作为常染色体显性阿尔茨海默病的病理生物标志物

目的：从显性遗传的阿尔茨海默病网络 (DIAN) 中识别突变携带者 (MC) 中的全局静息状态功能连接 (gFC) 特征。评估 gFC 的淀粉样蛋白 (A)、tau (T) 和神经变性 (N) 生物标志物，并估计症状发作 (EYO) 的年数。

更新日期：2021-04-18

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