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Mitofusins Mfn1 and Mfn2 are required to preserve glucose-but not incretin- stimulated beta cell connectivity and insulin secretion
bioRxiv - Molecular Biology Pub Date : 2021-08-13 , DOI: 10.1101/2020.04.22.055384
Eleni Georgiadou , Charanya Muralidharan , Michelle Martinez , Pauline Chabosseau , Alejandra Tomas , Fiona Yong Su Wern , Theodoros Stylianides , Stephen M. Rothery , Aida Di Gregorio , Isabelle Leclerc , Yusuf Ali , Amelia K. Linnemann , Tristan A. Rodriguez , Guy A. Rutter

Aims/hypothesis Mitochondrial glucose metabolism is essential for stimulated insulin release from pancreatic beta cells. Whether mitochondrial networks may be important for glucose or incretin sensing has yet to be determined.

中文翻译:

Mitofusins Mfn1 和 Mfn2 是维持葡萄糖而非肠促胰岛素刺激的 β 细胞连接和胰岛素分泌所必需的

目的/假设线粒体葡萄糖代谢对于刺激胰岛 β 细胞释放胰岛素至关重要。线粒体网络对于葡萄糖或肠促胰素传感是否重要尚待确定。
更新日期:2021-08-16
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