The Channichthyidae family (icefish) are the only known vertebrate species to be devoid of haemoglobin. Mitochondrial changes such as tight coupling of the mitochondria have facilitated sustained oxygen and respiratory activity in the fish. This makes it important to appreciate features in the sequence and structure of the proteins directly involved in proton transport, which could have physiological implications. ATP synthase subunit a ( ATP6 ) and subunit 8 ( ATP8 ) are proteins that function as part of the F 0 component (proton pump) of the F 0 F 1 complex. Both are encoded by the mitochondrial genome and involved in oxidative phosphorylation. To explore mitochondrial sequence variation for ATP6 and ATP8 we have gathered sequences and predicted structures of these two proteins of fish from the Notothenioidei sub-order, a sub-Antarctic species. We compared these with seven other vertebrate species in order to reveal whether there might be physiologically important differences that can help us to understand the unique biology of the icefish.

中文翻译：

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拟南芥鱼类中ATP合酶F0亚基6和8的序列和结构比较。

n鱼科（冰鱼）是唯一没有血红蛋白的已知脊椎动物。线粒体的紧密结合等线粒体变化促进了鱼类体内持续的氧气和呼吸活动。因此，重要的是要了解直接参与质子运输的蛋白质的序列和结构中可能具有生理意义的特征。ATP合酶亚基a（ATP6）和亚基8（ATP8）是作为F 0 F 1复合体的F 0成分（质子泵）的一部分起作用的蛋白质。两者均由线粒体基因组编码，并参与氧化磷酸化。为了探索ATP6和ATP8的线粒体序列变异，我们从Notothenioidei子阶（南极亚种）中收集了这两种鱼蛋白的序列并预测了其结构。