Vascular endothelial growth factors (VEGFs) are vital regulators of angiogenesis that are expressed in response to soluble mediators, such as cytokines and growth factors. Their physiologic functions include blood vessel formation, regulation of vascular permeability, stem cell and monocyte/macrophage recruitment and maintenance of bone homeostasis and repair. In addition, angiogenesis plays a pivotal role in chronic pathologic conditions, such as tumorigenesis, inflammatory immune diseases and bone loss. According to their prevalence, morbidity and mortality, inflammatory diseases affecting periodontal tissues and oral cancer are relevant non-communicable diseases. Whereas oral squamous cell carcinoma (OSCC) is considered one of the most common cancers worldwide, destructive inflammatory periodontal diseases, on the other hand, are amongst the most prevalent chronic inflammatory conditions affecting humans and also represent the main cause of tooth loss in adults. In the recent years, while knowledge regarding the role of VEGF signaling in common oral diseases is expanding, new potential translational applications emerge. In the present narrative review we aim to explore the role of VEGF signaling in oral cancer and destructive periodontal inflammatory diseases, with emphasis in its translational applications as potential biomarkers and therapeutic targets.

中文翻译：

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血管内皮生长因子：口腔非传染性疾病的转化观点。

血管内皮生长因子（VEGF）是重要的血管生成调节剂，可响应可溶性介质（例如细胞因子和生长因子）表达。它们的生理功能包括血管形成，血管通透性调节，干细胞和单核细胞/巨噬细胞募集以及骨稳态和修复的维持。另外，血管生成在慢性病理状况如肿瘤发生，炎性免疫疾病和骨丢失中起关键作用。根据其发病率，发病率和死亡率，影响牙周组织的炎性疾病和口腔癌是相关的非传染性疾病。另一方面，口腔鳞状细胞癌（OSCC）被认为是全球最常见的癌症之一，而破坏性炎症性牙周疾病则是，是影响人类的最普遍的慢性炎症性疾病之一，也是成年人牙齿脱落的主要原因。近年来，尽管有关VEGF信号在常见口腔疾病中的作用的知识正在扩大，但新的潜在翻译应用不断涌现。在本篇叙述性综述中，我们旨在探讨VEGF信号传导在口腔癌和破坏性牙周炎疾病中的作用，重点是将其作为潜在的生物标记物和治疗靶点进行翻译应用。