Abstract

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that is highly expressed in the brain. It influences neuronal survival, growth and acts as a control centre for neurotransmitters. It also plays a crucial role in learning and memory. Current evidence indicates that BDNF may be a possible neurotrophic factor that controls cognitive functions under normal and neuropathological conditions. Recent findings indicate a reduction in cognitive performance in individuals with Alzheimer’s disease (AD). This relationship between cognitive performance and AD is important for investigating both the time they overlap and the pathophysiological mechanism in each case. Therefore, this study reviewed the existing knowledge about BDNF and cognitive performance in the AD population. The findings support the idea that this tropic factor may be a potential biomarker for evaluating the changes in cognitive performance in AD.

摘要

脑源性神经营养因子（BDNF）是一种在大脑中高度表达的神经营养蛋白。它影响神经元的存活，生长并充当神经递质的控制中心。它在学习和记忆中也起着至关重要的作用。目前的证据表明，BDNF可能是正常和神经病理情况下控制认知功能的可能的神经营养因子。最近的发现表明患有阿尔茨海默氏病（AD）的人的认知能力下降。认知表现和AD之间的这种关系对于研究每种情况下它们重叠的时间和病理生理机制都非常重要。因此，本研究回顾了AD人群中有关BDNF和认知表现的现有知识。