Abstract

Nanoparticles are defined as objects, which have one, two or three external dimensions in the nanoscale, ranging from 1 to 100 nm (ISO/TR 18401:2017). In order to reduce vascular complications like thrombosis, infection and graft rejection, nanoparticle technologies show growing applications in the field of angiology and vascular surgery. The aim of this review is to evaluate the literature concerning the role of nanoparticles as a carrier for vascular agents and for improving biomaterial particularities used as substitutes in vascular surgery. While important advances have been achieved in vascular medicine with the emerging of nanotechnologies, much more fundamental and clinical work needs to be done before vascular implants and therapies reach the ideal state.

摘要

纳米粒子被定义为物体，在纳米尺度上具有一，两个或三个外部尺寸，范围从1到100 nm（ISO / TR 18401：2017）。为了减少血管并发症，例如血栓形成，感染和移植排斥，纳米颗粒技术在血管学和血管外科领域显示出越来越多的应用。这篇综述的目的是评估有关纳米颗粒作为血管药物载体的作用以及改善用作血管外科替代物的生物材料特性的文献。尽管随着纳米技术的出现，在血管医学上已经取得了重要的进展，但是在血管植入物和治疗达到理想状态之前，还需要做更多的基础和临床工作。