Abstract

A new flavonoid, saffloflavone , along with six known compounds, kaempferol-3-O-rutinoside, kaempferol-3-O-sophoroside, quercetin-3-O-β-d-glucoside, quercetin-7-O-β-d-glucoside, luteolin-7-O-β-d-glucoside and kaempferol 3-O-β-d-glucoside were isolated from the flowers of Carthamus tinctorius L. All the structures were determined by interpretation of their spectroscopic data. The cardioprotective effects of all the isolates against oxidative stress of H9c2 cells induced by H₂O₂ were investigated. The results showed that compounds 4–6 exhibited protective effects against of H9c2 cells injury induced by H₂O_2.

摘要

一种新的类黄酮，saffloflavone，沿着具有六个已知化合物，山柰酚-3- ø -rutinoside，山柰酚-3- ø -sophoroside，槲皮素-3- ø - β - d葡糖苷，槲皮素-7- ø - β - d -从红花的花中分离得到葡萄糖苷，木犀草素-7- O - β - d-葡萄糖苷和山奈酚3- O - β - d-葡萄糖苷。L.所有结构都是通过解释其光谱数据确定的。研究了所有分离株对H ₂ O ₂诱导的H9c2细胞氧化应激的心脏保护作用。结果表明，化合物4 - 6个表现出对由H诱导的H9c2细胞损伤的保护作用的₂ Ò _2。