Abstract

Two new flavanoids fissistiganoids A and B (1 and 2), together with two known pterocarpans derivatives (3 and 4), were isolated from the stems of Fissistigma tungfangense. The structures of these compounds were elucidated using comprehensive spectroscopic methods. The absolute configurations of fissistiganoids A and B (1 and 2) were determined by comparing their ECD spectra with quantum-mechanics ECD calculations. The inhibitory activities of all compounds against three cancer cell lines HeLa, MCF-7 and A549 were evaluated. Compounds 1–4 showed moderate inhibitory effects on HeLa, MCF-7 and A549 cells with IC₅₀ values ranging from 12.5 to 42.3 μM.

摘要

从Fissistigma tungfangense的茎中分离出了两个新的类黄酮类纤维类抗坏血酸类化合物A和B（1和2），以及两个已知的翼果类衍生物（3和4）。使用全面的光谱学方法阐明了这些化合物的结构。通过将它们的ECD谱图与量子力学ECD计算结果进行比较，确定了类异黄烷类化合物A和B（1和2）的绝对构型。评估了所有化合物对三种癌细胞系HeLa，MCF-7和A549的抑制活性。化合物1-4对HeLa，MCF-7和A549细胞具有中等抑制作用，IC ₅₀值范围从12.5至42.3  μ M.