ABSTRACT

To evaluate the relation between the sensitization to molecular components of inhalant allergens and the occurrence of food reactions in atopic dermatitis patients. Another aim is to evaluate the semi-quantification results of the ISAC Multiplex testing to reveal the relevance of the leading allergens. The complete dermatological and allergological examination including the examination of the sensitization to molecular components with Multiplex ISAC testing was performed. The food reactions to examined food allergens were confirmed in the open exposure test (history). Altogether 100 atopic dermatitis patients were examined – 48 men, 52 women, the average age 40.9 years. The leading molecular components are cysteine protease (Der f 1, Der p 1), NPC2 protease (Der f 2, Der p 2), Acidic glycoprotein (Alt a 1), PR 10 proteins (Bet v 1, Mal d 1, Aln g 1 and Cor 1.04), lipocalins (Can f 1, Fel d 4, Mus m 1, Equ c 1), uteroglobulin (Fel d 1), Kallikrein (Can f 5) and molecular components of Timothy and Bermuda grass (glycoprotein). The significantly higher occurrence of sensitization to molecular components Aln g 1, Bet v 1, Phl p 1, 2, 4, 5, 6, 11 was confirmed in patients suffering from reactions to peanuts, hazelnuts, celery, apple and peach.

摘要

评价过敏性皮炎患者对吸入性过敏原分子成分的致敏作用与食物反应发生之间的关系。另一个目的是评估ISAC多重检测的半定量结果，以揭示主要过敏原的相关性。进行了完整的皮肤病学和变应性检查，包括使用Multiplex ISAC测试检查对分子成分的敏感性。在公开暴露测试（历史记录）中确认了对所检查食物过敏原的食物反应。共检查了100例特应性皮炎患者-男48例，女52例，平均年龄40.9岁。主要的分子成分是半胱氨酸蛋白酶（Der f 1，Der p 1），NPC2蛋白酶（Der f 2，Der p 2），酸性糖蛋白（Alt a 1），PR 10蛋白（Bet v 1，Mal d 1，Aln g 1和Cor 1.04），脂蛋白（Can f 1，Fel d 4，Mus m 1，Equ c 1），子宫球蛋白（Fel d 1），激肽释放酶（Can f 5）以及蒂莫西和百慕大草的分子成分（糖蛋白）。在对花生，榛子，芹菜，苹果和桃子有反应的患者中，证实了对分子成分Aln g 1，Bet v 1，Phl p 1，2，4，5，6，11的敏化作用明显增加。