Abstract

Objective

This study aimed to perform an updated meta-analysis to explore the clinical, diagnostic and prognostic values of circRNAs in osteosarcoma.

Methods

: PubMed, Web of Science, EMBASE, Scopus and Cochrane Library were systematically searched up to December 15, 2020. Eligible studies regarding the relationship between circRNAs levels and clinicopathological, diagnostic and prognostic values in osteosarcoma were included for meta-analysis.

Results

31 studies involving 1979 osteosarcoma patients were enrolled, with twenty-two studies on clinicopathological parameters, eleven on diagnosis and twenty-three on prognosis. For clinical parameters, overexpression of oncogenic circRNAs was intimately correlated with larger tumor size, advanced Enneking stage, poor differentiation, and distant metastasis (DM). In contrast, the downregulated circRNAs showed negative correlation with Enneking stage and DM. For the diagnostic values, the summary area under the curve of circRNA for the discriminative efficacy between osteosarcoma patients and non-cancer counterparts was estimated to be 0.87, with a weighted sensitivity of 0.79, specificity of 0.81, respectively. For the prognostic significance, oncogenic circRNAs had poor overall survival (OS) and disease-free survival, while elevated expression of tumor-suppressor circRNAs were closely related to longer OS.

Conclusion

This study showed that aberrantly expressed circRNA signatures could serve as potential biomarkers in diagnosis and prognosis in osteosarcoma.

中文翻译：

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骨肉瘤中环状RNA表达失调的诊断和预后意义

摘要

目的

这项研究旨在进行更新的荟萃分析，以探讨circRNA在骨肉瘤中的临床，诊断和预后价值。

方法

：截至2020年12月15日，已对PubMed，Web of Science，EMBASE，Scopus和Cochrane图书馆进行了系统搜索。纳入有关circRNA水平与骨肉瘤临床病理，诊断和预后价值之间关系的合格研究以进行荟萃分析。

结果

招募了31项涉及1979年骨肉瘤患者的研究，其中包括22项临床病理参数研究，11项诊断和23项预后研究。对于临床参数，致癌circRNA的过表达与更大的肿瘤大小，晚期Enneking阶段，差的分化和远处转移（DM）密切相关。相反，下调的circRNA与Enneking阶段和DM呈负相关。对于诊断值，circRNA曲线下的骨肉瘤患者和非癌肉瘤患者的鉴别功效的总面积估计为0.87，加权敏感性为0.79，特异性为0.81。出于预后的意义，致癌性circRNA具有较差的总体生存率（OS）和无病生存率，

结论

这项研究表明，异常表达的circRNA特征可以作为骨肉瘤诊断和预后的潜在生物标志物。