The synthesis of a sulfate-modified dendritic peptide amphiphile and its self-assembly into one-dimensional rod-like architectures in aqueous medium is reported. The influence of the ionic strength on the supramolecular polymerization was probed via circular dichroism spectroscopy and cryogenic transmission electron microscopy. Physiological salt concentrations efficiently screen the charges of the dendritic building block equipped with eight sulfate groups and trigger the formation of rigid supramolecular polymers. Since multivalent sulfated supramolecular structures mimic naturally occurring L-selectin ligands, the corresponding affinity was evaluated using a competitive SPR binding assay and benchmarked to an ethylene glycol-decorated supramolecular polymer.

中文翻译：

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硫酸化树突状肽两亲物超分子聚合成多价L-选择素结合剂

据报道，硫酸盐修饰的树突状肽两亲物的合成及其在水介质中的自组装成一维杆状结构。离子强度对超分子聚合的影响通过圆二色光谱和低温透射电子显微镜进行了探讨。生理盐浓度可有效筛选配备有八个硫酸根基团的树突状结构单元的电荷，并触发形成刚性超分子聚合物。由于多价硫酸化的超分子结构模拟了天然存在的L-选择素配体，因此使用竞争性SPR结合测定法评估了相应的亲和力，并以乙二醇修饰的超分子聚合物为基准。