Capillary electrophoresis is a powerful technique for the analysis of polar chiral compounds and has been widely accepted for analytical enantioseparations of drug compounds in pharmaceuticals and biological media. In addition, many mechanistic studies have been conducted in an attempt to rationalize enantioseparations in combination with spectroscopic and computational techniques. The present review will focus on recent examples of mechanistic aspects and summarize recent applications of stereoselective pharmaceutical and biomedical analysis published between January 2017 and November 2020. Various separation modes including electrokinetic chromatography in combination with several detection modes including laser-induced fluorescence, mass spectrometry and contactless conductivity detection will be discussed. A general trend also observed in other analytical techniques is the application of quality by design principles in method development and optimization.

中文翻译：

---

毛细管电泳对映体在药物分析中的进展（2017-2020）

毛细管电泳是一种分析极性手性化合物的强大技术，已被广泛用于药物和生物介质中药物化合物的分析对映体分离。此外，已经进行了许多机械研究，试图结合光谱和计算技术使对映体分离合理化。本综述将重点关注机械方面的最新示例，并总结 2017 年 1 月至 2020 年 11 月发表的立体选择性药物和生物医学分析的最新应用。包括电动色谱在内的各种分离模式与激光诱导荧光、质谱和将讨论非接触式电导检测。