Chalcone-derived pyrimidine is a well-known heterocyclic compound that is commonly present in ribonucleic acid (RNA) and deoxyribonucleic acid (DNA) bio-isosteres. Pyrimidine derivatives are effective in both the electronic industry and drug industries. This review highlights the synthesis of pyrimidines, namely mono-pyrimidine, bis-pyrimidine, fused pyrimidine, symmetric, and asymmetric pyrimidine via one-pot and two-pot methods. The one-pot method is the direct reaction of amino derivatives with aldehydes and acetophenones, whereas the two-pot method is frequently reported for the synthesis of chalcone before the cyclization to a pyrimidine. This review is important in organic synthesis, particularly in the heterocyclic field, regarding pyrimidines and their significance in therapeutic and electronic industries.

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查耳酮衍生嘧啶的一锅法和二锅法合成及应用

查尔酮衍生的嘧啶是众所周知的杂环化合物，通常存在于核糖核酸 (RNA) 和脱氧核糖核酸 (DNA) 生物等排体中。嘧啶衍生物在电子工业和制药工业中均有效。本综述重点介绍了通过一锅法和两锅法合成嘧啶，即单嘧啶、双嘧啶、稠合嘧啶、对称和不对称嘧啶。一锅法是氨基衍生物与醛和苯乙酮的直接反应，而二锅法经常被报道用于在环化成嘧啶之前合成查尔酮。这篇综述在有机合成中很重要，特别是在杂环领域，关于嘧啶及其在治疗和电子工业中的重要性。