Extracellular vesicles mediate cellular interactions in renal diseases—Novel views of intercellular communications in the kidney,Journal of Cellular Physiology

当前位置： X-MOL 学术 › J. Cell. Physiol. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Extracellular vesicles mediate cellular interactions in renal diseases—Novel views of intercellular communications in the kidney
Journal of Cellular Physiology ( IF 4.5 ) Pub Date : 2021-01-11 , DOI: 10.1002/jcp.30268
Ping L Zhang ₁ , Ming-Lin Liu _{2,

3}

Affiliation

The kidney is a complicated and important internal organ receiving approximately 20% of the cardiac output and mediates numerous pathophysiologic actions. These include selectively filtering macromolecules of the blood, exquisite reclaimation of electrolyctes, urine concentration via an elegant osmotic mechanism, and excretion of an acid load. In addition, the renal tubules carry out secretory functions and produce hormones and cytokines. The kidney receives innervation and hormonal regulation. Therefore, dysfunction of the kidney leads to retention of metabolic waste products, and/or significant proteinuria and hematuria. In the past several decades, the role of extracellular vesicles (EVs) in intercellular communications, and the uptake of EVs by recipient cells through phagocytosis and endocytosis have been elucidated. The new knowledge on EVs expands over the classical mechanisms of cellular interaction, and may change our way of thinking of renal pathophysiology in the subcellular scale. Based on some ultrastructural discoveries in the kidney, this review will focus on the role of EVs in intercellular communications, their internalization by recipient cells, and their relationship to renal pathology.

中文翻译：

细胞外囊泡介导肾脏疾病中的细胞相互作用——肾脏细胞间通讯的新观点

肾脏是一个复杂而重要的内脏器官，接受大约 20% 的心输出量并介导许多病理生理作用。这些包括选择性过滤血液中的大分子、精细回收电解质、通过优雅的渗透机制浓缩尿液以及排泄酸负荷。此外，肾小管执行分泌功能并产生激素和细胞因子。肾脏接受神经支配和激素调节。因此，肾功能障碍导致代谢废物的滞留和/或明显的蛋白尿和血尿。在过去的几十年中，细胞外囊泡 (EVs) 在细胞间通讯中的作用，以及受体细胞通过吞噬作用和内吞作用对 EVs 的摄取已被阐明。关于 EV 的新知识扩展了细胞相互作用的经典机制，并可能改变我们在亚细胞范围内对肾脏病理生理学的思考方式。基于肾脏中的一些超微结构发现，本综述将重点关注 EV 在细胞间通讯中的作用、它们被受体细胞内化以及它们与肾脏病理学的关系。

更新日期：2021-01-11

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11