PURPOSE Aggression-irritability is the most commonly encountered antiepileptic-drug-induced psychiatric adverse effects. In this cross-sectional study, we tried to assess antiepileptic-drug-induced aggression in patients with epilepsy (PWE) with a standardized rating scale. METHODS Two hundred sixty-six consecutive outpatients receiving treatment for epilepsy with antiepileptic drugs (AEDs) were initially examined, and the effects of the investigated drugs in regard to aggression were investigated using the Buss-Perry Aggression Questionnaire (BAQ). We compared BAQ scores as a function of a specific class of AEDs, levetiracetam (LEV), lacosamaide (LCM), perampanel (PER), and carbamazepine (CBZ), and determined whether AED type had a relationship with aggression. Additionally, the association of BAQ score with other clinico-demographic variables was also assessed. RESULTS One-way ANOVA revealed that the LEV group had a significantly higher mean BAQ score as compared to the CBZ (P = 0.001) and LCM (P = 0.029) groups for total score. In subscale analysis, the LEV group had higher scores than the CBZ group for the physical aggression (p = 0.01), verbal aggression (p = 0.02) and hostility (p = 0.01) subscales, while the LEV group had a significantly higher mean score than the LCM group for hostility (p = 0.025). In multiple regression analysis, LEV had a statistically significant impact on increased total BAQ score (B = 0.119, p = 0.049). In contrast, CBZ (B = -0.191, p = 0.002), older age at epilepsy onset (B = -0.269, p = 0.000) and female gender (B = -0.210, p = 0.000) had a significant association with lower total BAQ score. CONCLUSIONS Our results indicate that LEV is associated with increased aggression, while CBZ and LCM showed effects to reduce aggression.

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攻击性作为新型 AED 对癫痫患者的精神副作用：基于 Buss-Perry 攻击性问卷的横断面研究

目的 攻击性-易怒是最常见的抗癫痫药物引起的精神不良反应。在这项横断面研究中，我们尝试使用标准化的评分量表评估癫痫 (PWE) 患者的抗癫痫药物诱导的攻击行为。方法 对 266 名接受抗癫痫药物 (AEDs) 癫痫治疗的连续门诊患者进行初步检查，并使用 Buss-Perry 攻击性问卷 (BAQ) 调查所研究药物对攻击性的影响。我们将 BAQ 评分作为特定类别 AED、左乙拉西坦 (LEV)、拉科胺 (LCM)、吡仑帕奈 (PER) 和卡马西平 (CBZ) 的函数进行比较，并确定 AED 类型是否与攻击性有关。此外，还评估了 BAQ 评分与其他临床人口统计学变量的关联。结果 单因素方差分析显示，与 CBZ (P = 0.001) 和 LCM (P = 0.029) 组相比，LEV 组的平均 BAQ 得分显着更高。在分量表分析中，LEV 组在身体攻击 (p = 0.01)、言语攻击 (p = 0.02) 和敌意 (p = 0.01) 分量表上的得分高于 CBZ 组，而 LEV 组的平均得分明显高于 CBZ 组比 LCM 组的敌意（p = 0.025）。在多元回归分析中，LEV 对增加的总 BAQ 得分有统计学意义的影响（B = 0.119，p = 0.049）。相比之下，CBZ (B = -0.191, p = 0.002)、癫痫发病年龄较大 (B = -0.269, p = 0.000) 和女性 (B = -0.210, p = 0)。000) 与较低的 BAQ 总分显着相关。结论 我们的结果表明，LEV 与攻击性增加有关，而 CBZ 和 LCM 显示出减少攻击性的效果。