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Spliceosome-Targeted Therapies Induce dsRNA Responses
Immunity ( IF 25.5 ) Pub Date : 2021-01-12 , DOI: 10.1016/j.immuni.2020.12.012
Charles A Ishak 1 , Helen Loo Yau 2 , Daniel D De Carvalho 2
Affiliation  

In a recent issue of Cell, Bowling et al. describe a mechanism by which spliceosome-targeted therapies result in intron-containing transcripts that form double-stranded RNAs (dsRNAs), thereby activating tumor antiviral signaling (viral mimicry) and downstream adaptive immunity.



中文翻译:

剪接体靶向疗法诱导 dsRNA 反应

在最近一期的Cell 中,Bowling 等人。描述了一种机制,通过该机制,剪接体靶向疗法导致含有内含子的转录物形成双链 RNA(dsRNA),从而激活肿瘤抗病毒信号(病毒模拟)和下游适应性免疫。

更新日期:2021-01-12
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