This study aimed to compare whether the characteristics of Parkinson’s disease (PD) patients between probably rapid eye movement sleep behavior disorder (RBD) and confirmed RBD versus non-RBD are differing using a meta-analytic approach. We systematically searched PubMed, EmBase, and the Cochrane library for eligible studies throughout October 2018 in this meta-analysis. The clinical characteristics of PD patients presented with probably RBD, confirmed RBD, or non-RBD were analyzed. The pooled odds ratios and weighted mean differences with corresponding 95 % confidence intervals were calculated for categories and continuous data, respectively. All the pooled analyses were conducted using random-effects model. Forty-seven studies recruited a total of 8019 PD patients were included in the final meta-analysis. The summary results indicated significant differences between probable RBD and non-RBD for PD duration, levodopa dosage daily, Hoehn-Yahr stage, UPDRS-III, UPDRS-motor score, UPDRS activity of daily living, Epworth Sleepiness scale, male percentage, dyskinesia, orthostatic hypotension, constipation, and fluctuations present. Moreover, confirmed RBD versus non-RBD showed significant differences for age, PD duration, levodopa dosage daily, Mini-Mental State Examination, Hoehn-Yahr stage, UPDRS-motor score, Epworth Sleepiness scale, male percentage, dyskinesia, hallucination, insomnia, dementia, orthostatic hypotension, falls, and fluctuations present. Furthermore, the difference of confirmed RBD versus non-RBD was significantly elderly than probable RBD versus non-RBD. Moreover, PD patients with confirmed RBD with lower Mini-Mental State Examination as compared with probable RBD corresponding PD patients without RBD. In addition, PD patients with confirmed RBD versus probable RBD was associated with high Hoehn-Yahr stage as compared with non-RBD. Finally, patients with confirmed RBD with high incidence of insomnia as compared with probable RBD corresponding PD patients without RBD. The results provide the comprehensive differences in the patients’ characteristics among probable RBD, confirmed RBD, and non-RBD in PD patients.

本研究旨在比较帕金森病 (PD) 患者在可能的快速眼动睡眠行为障碍 (RBD) 和确诊的 RBD 与非 RBD 之间的特征是否使用荟萃分析方法不同。我们在 2018 年 10 月的整个荟萃分析中系统地搜索了 PubMed、EmBase 和 Cochrane 图书馆，寻找符合条件的研究。分析了可能表现为 RBD、确诊 RBD 或非 RBD 的 PD 患者的临床特征。分别计算类别和连续数据的合并优势比和加权平均差异以及相应的 95% 置信区间。所有汇总分析均使用随机效应模型进行。最终的荟萃分析纳入了 47 项研究，共招募了 8019 名 PD 患者。总结结果表明 PD 持续时间、左旋多巴每日剂量、Hoehn-Yahr 分期、UPDRS-III、UPDRS-运动评分、UPDRS 日常生活活动、Epworth 嗜睡量表、男性百分比、运动障碍、存在体位性低血压、便秘和波动。此外，经证实的 RBD 与非 RBD 在年龄、PD 持续时间、左旋多巴每日剂量、简易精神状态检查、Hoehn-Yahr 分期、UPDRS 运动评分、Epworth 嗜睡量表、男性百分比、运动障碍、幻觉、失眠、痴呆、直立性低血压、跌倒和波动存在。此外，确认的 RBD 与非 RBD 的差异显着高于可能的 RBD 与非 RBD。而且，与没有 RBD 的可能 RBD 对应的 PD 患者相比，具有较低简易精神状态检查的确诊 RBD 的 PD 患者。此外，与非 RBD 相比，具有确诊 RBD 与可能 RBD 的 PD 患者与高 Hoehn-Yahr 分期相关。最后，与没有 RBD 的可能 RBD 对应的 PD 患者相比，确诊 RBD 患者失眠的发生率高。结果提供了PD患者中可能RBD、确诊RBD和非RBD患者特征的综合差异。与可能的 RBD 对应的无 RBD 的 PD 患者相比，确诊 RBD 的患者失眠发生率高。结果提供了PD患者中可能RBD、确诊RBD和非RBD患者特征的综合差异。与可能的 RBD 对应的无 RBD 的 PD 患者相比，确诊 RBD 的患者失眠发生率高。结果提供了PD患者中可能RBD、确诊RBD和非RBD患者特征的综合差异。