BACKGROUND Increasing clinical and scientific attention is given to the transition of neurological stages from child to adult. Data on brain plasticity during adolescence is interesting for providing adequate evidence-based medical attention to neurological conditions in this population. Acquired aphasia is well described in adults and children, but not in adolescence. OBJECTIVE We describe a 5-year follow-up of language in three adolescent subjects with post-brain injury aphasia. METHODS We analysed and scored formal aspects of language three times, language hemispheric dominance twice with dichotic listening test and functional magnetic resonance imaging (fMRI) brain activation patterns that supported expressive and comprehensive language during the recovery period. RESULTS We found similarities to both paediatric and adult aphasia in these three adolescents. While the level of recovery resembled that of children with aphasia, a more efficient language rehabilitation occurred in those who remained with left hemispheric dominance in the chronic stage, as it is reported in adults. CONCLUSIONS Our analysis and long-term follow-up provide data for a better understanding on how the injured brain matures during adolescence. More studies with larger samples will help to understand the function of the remaining networks and the recovery from injury in this particular age group.

中文翻译：

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过渡期的神经可塑性：青少年大脑如何从失语症中恢复。一项试点研究

背景越来越多的临床和科学关注神经学阶段从儿童到成人的转变。青春期大脑可塑性的数据对于为该人群的神经系统疾病提供足够的循证医学关注很有趣。获得性失语症在成人和儿童中有很好的描述，但在青春期则不然。目标 我们描述了对三名患有脑损伤后失语症的青少年受试者的 5 年语言随访。方法我们对语言的形式方面进行了三次分析和评分，并通过双耳听力测试和功能性磁共振成像 (fMRI) 大脑激活模式对语言的半球优势进行了两次分析和评分，这些模式在恢复期间支持表达性和综合性语言。结果 我们发现这三名青少年与儿科和成人失语症有相似之处。虽然恢复水平与失语症儿童相似，但在慢性阶段仍保持左半球优势的儿童的语言康复效率更高，正如在成人中报道的那样。结论我们的分析和长期随访提供了数据，可以更好地了解受伤的大脑在青春期是如何成熟的。对更大样本进行更多研究将有助于了解剩余网络的功能以及该特定年龄组的损伤恢复情况。结论我们的分析和长期随访提供了数据，可以更好地了解受伤的大脑在青春期是如何成熟的。对更大样本进行更多研究将有助于了解剩余网络的功能以及该特定年龄组的损伤恢复情况。结论我们的分析和长期随访提供了数据，可以更好地了解受伤的大脑在青春期是如何成熟的。对更大样本进行更多研究将有助于了解剩余网络的功能以及该特定年龄组的损伤恢复情况。