The microvascular networks in the body of vertebrates consist of the smallest vessels such as arterioles, capillaries, and venules. The flow of RBCs through these networks ensures the gas exchange in as well as the transport of nutrients to the tissues. Any alterations in this blood flow may have severe implications on the health state. Since the vessels in these networks obey dimensions similar to the diameter of RBCs, dynamic effects on the cellular scale play a key role. The steady progression in the numerical modeling of RBCs, even in complex networks, has led to novel findings in the field of hemodynamics, especially concerning the impact and the dynamics of lingering events, when a cell meets a branch of the network. However, these results are yet to be matched by a detailed analysis of the lingering experiments in vivo. To quantify this lingering effect in in vivo experiments, this study analyzes branching vessels in the microvasculature of Syrian golden hamsters via intravital microscopy and the use of an implanted dorsal skinfold chamber. It also presents a detailed analysis of these lingering effects of cells at the apex of bifurcating vessels, affecting the temporal distribution of plasmatic zones of blood flow in the branches, even causing a partial blockage in severe cases.

中文翻译：

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微血管血流中的挥之不去的动力学

脊椎动物体内的微血管网络由最小的血管组成，例如小动脉、毛细血管和小静脉。红细胞通过这些网络的流动确保了气体交换以及营养物质向组织的运输。这种血流的任何变化都可能对健康状况产生严重影响。由于这些网络中的血管遵循与红细胞直径相似的尺寸，因此对细胞尺度的动态影响起着关键作用。即使在复杂网络中，RBC 数值建模的稳步进展也导致了血液动力学领域的新发现，特别是当细胞遇到网络分支时，挥之不去的事件的影响和动力学。然而，这些结果尚未与体内挥之不去的实验的详细分析相匹配。为了量化体内实验中这种挥之不去的影响，本研究通过活体显微镜和使用植入的背侧皮褶室分析了叙利亚金仓鼠微血管系统中的分支血管。它还详细分析了分叉血管顶端细胞的这些挥之不去的影响，影响分支中血流血浆区的时间分布，甚至在严重的情况下导致部分阻塞。