In this paper, the structural and functional imaging changes associated with sporadic and genetic Parkinson’s disease and atypical Parkinsonian variants are reviewed. The role of imaging for supporting diagnosis and detecting subclinical disease is discussed, and the potential use and drawbacks of using imaging biomarkers for monitoring disease progression is debated. Imaging changes associated with nonmotor complications of PD are presented. The similarities and differences in imaging findings in Lewy body dementia, Parkinson’s disease dementia, and Alzheimer’s disease are discussed.

中文翻译：

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与帕金森症相关的家族性和散发性神经退行性疾病的影像学

本文综述了与散发性和遗传性帕金森病以及非典型帕金森病变异相关的结构和功能影像学变化。讨论了成像在支持诊断和检测亚临床疾病方面的作用，并讨论了使用成像生物标志物监测疾病进展的潜在用途和缺点。提出了与 PD 非运动并发症相关的影像学变化。讨论了路易体痴呆、帕金森病痴呆和阿尔茨海默病影像学表现的异同。