There are over 3 million people in sub-Saharan Africa (SSA) aged 50 and over living with HIV. HIV and combined antiretroviral therapy (cART) exposure may accelerate the ageing in this population, and thus increase the prevalence of premature frailty. There is a paucity of data on the prevalence of frailty in an older HIV + population in SSA and screening and diagnostic tools to identify frailty in SSA. Patients aged ≥ 50 were recruited from a free Government HIV clinic in Tanzania. Frailty assessments were completed, using 3 diagnostic and screening tools: the Fried frailty phenotype (FFP), Clinical Frailty Scale (CFS) and Brief Frailty Instrument for Tanzania (B-FIT 2). The 145 patients recruited had a mean CD4 + of 494.84 cells/µL, 99.3% were receiving cART and 72.6% were virally suppressed. The prevalence of frailty by FFP was 2.758%. FFP frailty was significantly associated with female gender (p = 0.006), marital status (p = 0.007) and age (p = 0.038). Weight loss was the most common FFP domain failure. The prevalence of frailty using the B-FIT 2 and the CFS was 0.68%. The B-FIT 2 correlated with BMI (r = − 0.467, p = 0.0001) and CD4 count in females (r = − 0.244, p = 0.02). There is an absence of frailty in this population, as compared to other clinical studies. This may be due to the high standard of HIV care at this Government clinic. Undernutrition may be an important contributor to frailty. It is unclear which tool is most accurate for detecting the prevalence of frailty in this setting as levels of correlation are low.

撒哈拉以南非洲 (SSA) 有超过 300 万 50 岁及以上的艾滋病毒感染者。HIV 和联合抗逆转录病毒疗法 (cART) 暴露可能会加速这一人群的老龄化，从而增加过早衰弱的患病率。缺乏关于 SSA 中老年 HIV + 人群虚弱患病率的数据以及用于识别 SSA 虚弱的筛查和诊断工具。≥ 50 岁的患者是从坦桑尼亚的一个免费政府 HIV 诊所招募的。使用 3 种诊断和筛查工具完成了虚弱评估：Fried 虚弱表型 (FFP)、临床虚弱量表 (CFS) 和坦桑尼亚简要虚弱量表 (B-FIT 2)。招募的 145 名患者的平均 CD4 + 为 494.84 个细胞/μL，99.3% 正在接受 cART，72.6% 被病毒抑制。FFP 的虚弱患病率为 2.758%。p  = 0.006)、婚姻状况 ( p  = 0.007) 和年龄 ( p  = 0.038)。减肥是最常见的 FFP 域失败。使用 B-FIT 2 和 CFS 的虚弱患病率为 0.68%。B-FIT 2 与 女性的体重指数 ( r  = − 0.467, p = 0.0001) 和 CD4 计数相关 ( r  = − 0.244, p  = 0.02)。与其他临床研究相比，该人群不存在虚弱。这可能是由于这家政府诊所的艾滋病毒护理标准很高。营养不良可能是导致虚弱的一个重要因素。由于相关性水平较低，目前尚不清楚哪种工具最准确地检测这种情况下的虚弱患病率。