Objectives

This study aimed to provide an exhaustive description of criteria and methodological recommendations for evaluating them in health technology assessment (HTA) in Western and Asian countries.

Methods

We conducted a system literature review of HTA-related guidelines by searching the websites of HTA agencies and related data sources. The guidelines, reports, or recommendations introducing the HTA evaluation methods, processes, decision-making frameworks, and criteria for priority setting were eligible to be included. The review was limited to guidelines from countries belonging to the European Network for Health Technology Assessment (EUnetHTA) and HTAsiaLink organisations and other countries with well-established available guidelines.

Results

A total of 52 guidelines from 24 countries were identified, including 13 countries from the EUnetHTA organisation, 9 countries from the HTAsiaLink organisation and 2 other countries (Canada and the USA). A strong consensus was observed among the HTA agencies on the core set of criteria including efficacy or effectiveness, cost-effectiveness, safety, and budget impact. More similarities were observed than differences in methodological recommendations for clinical and economic evaluations among the agencies.

Conclusions

Substantial convergence is seen in the criteria included in the HTA process, as well as the methods to evaluate and quantify them. Further efforts are needed to verify whether the criteria identified from the guidelines are incorporated in real HTA decisions, and how they are assessed and weighted in practice.

中文翻译：

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在卫生技术评估中考虑了哪些标准以及如何评估它们？西方和亚洲国家使用的方法学指南回顾

目标

本研究旨在详尽描述西方和亚洲国家在卫生技术评估 (HTA) 中对其进行评估的标准和方法学建议。

方法

我们通过搜索 HTA 机构的网站和相关数据源，对 HTA 相关指南进行了系统文献回顾。介绍 HTA 评估方法、流程、决策框架和优先级设置标准的指南、报告或建议有资格被包括在内。审查仅限于属于欧洲卫生技术评估网络 (EUnetHTA) 和 HTAsiaLink 组织的国家以及其他拥有完善可用指南的国家的指南。

结果

共确定了来自 24 个国家的 52 条指南，其中包括 EUnetHTA 组织的 13 个国家、HTAsiaLink 组织的 9 个国家和其他 2 个国家（加拿大和美国）。HTA 机构在核心标准集上达成了强烈的共识，包括功效或有效性、成本效益、安全性和预算影响。观察到的相似之处多于机构间临床和经济评估方法学建议的差异。

结论

在 HTA 过程中包含的标准以及评估和量化这些标准的方法中，可以看到实质性的趋同。需要进一步努力验证指南中确定的标准是否纳入实际 HTA 决策中，以及如何在实践中对其进行评估和加权。