A simple strategy for simultaneously enhancing photostability and mitochondrial-targeting stability of near-infrared fluorophores for multimodal imaging-guided photothermal therapy,Journal of Materials Chemistry B

当前位置： X-MOL 学术 › J. Mater. Chem. B › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

A simple strategy for simultaneously enhancing photostability and mitochondrial-targeting stability of near-infrared fluorophores for multimodal imaging-guided photothermal therapy
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-30 , DOI: 10.1039/d0tb02674c
Shuping Zhang _{1,

2,

3,

4,

5} , Hua Chen _{1,

2,

3,

4,

5} , Liping Wang _{1,

2,

3,

4,

5} , Chunli Liu _{1,

2,

3,

4,

5} , Li Liu _{1,

2,

3,

4,

5} , Yu Sun _{1,

2,

3,

4,

5} , Xing-can Shen _{1,

2,

3,

4,

5}

Affiliation

Near-infrared fluorophores are emerging as promising molecular tools for cancer theranostics because of their inherent biodegradability, low toxicity, and synthetic flexibility. However, they still suffer from several limitations, such as poor photostability and insufficient organelle-targeting stability during photothermal therapy. In this work, we introduce an “aldehyde functionalization” strategy for simultaneously enhancing photostability and mitochondria-immobilization of near-infrared fluorophores for the first time. Based on the proposed strategy, representative near-infrared organic molecules, namely AF-Cy, were rationally designed and synthesized. Upon aldehyde modification, the AF-Cy dyes displayed both remarkable photostability and mitochondrial-targeting stability. The strong absorption in the near-infrared region confers the AF-Cy dyes with outstanding fluorescent/photoacoustic imaging and photothermal therapy capabilities. Finally, in vitro and in vivo studies revealed the enhanced performance in inhibiting the growth of breast tumors under NIR laser radiation, and these results suggested the strong potential of AF-Cy dyes as efficient multimodal imaging-guided photothermal therapy agents, further highlighting the value of this simple strategy in the design high performance near-infrared fluorophores for tumor theranostics.

中文翻译：

同时增强多模式成像引导光热疗法的近红外荧光团的光稳定性和线粒体靶向稳定性的简单策略

近红外荧光团因其固有的生物降解性，低毒性和合成灵活性而成为癌症治疗学的有前途的分子工具。但是，它们仍然受到一些限制，例如光稳定性差，并且在光热治疗过程中细胞器靶向稳定性不足。在这项工作中，我们首次引入了一种“醛功能化”策略，以同时增强近红外荧光团的光稳定性和线粒体固定性。基于所提出的策略，合理地设计和合成了代表性的近红外有机分子，即AF-Cy。醛改性后，AF-Cy染料显示出显着的光稳定性和线粒体靶向稳定性。AF-Cy染料具有出色的荧光/光声成像和光热治疗能力，可在近红外区域吸收强光。最后，体外和体内研究显示在近红外激光辐射下抑制乳腺肿瘤生长的性能增强，这些结果表明AF-Cy染料作为高效的多模态成像引导光热治疗剂具有巨大潜力，进一步凸显了其价值。这种简单策略的成功之处在于设计用于肿瘤治疗的高性能近红外荧光团。

更新日期：2021-01-11

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11