Nanozymes go oral: nanocatalytic medicine facilitates dental health,Journal of Materials Chemistry B

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Nanozymes go oral: nanocatalytic medicine facilitates dental health
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-24 , DOI: 10.1039/d0tb02763d
Xiaohang Chen† _{1,

2,

2,

3,

4} , Helin Xing† _{3,

5,

6,

7,

8} , Zilan Zhou _{1,

2,

2,

3,

4} , Yujia Hao _{1,

2,

2,

3,

4} , Xiaoxuan Zhang _{1,

2,

2,

3,

4} , Feng Qi _{9,

10,

11,

12} , Jing Zhao _{1,

2,

2,

3,

4} , Lizeng Gao _{3,

13,

14,

15,

16} , Xing Wang _{1,

2,

2,

3,

4}

Affiliation

Shanxi Medical University School and Hospital of Stomatology
Taiyuan 030001
China
Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials
Department of Prosthodontics
Beijing Stomatological Hospital and School of Stomatology
Capital Medical University
Beijing
Department of Mechanical and Aerospace Engineering
University of Missouri
Columbia
USA
CAS Engineering Laboratory for Nanozyme
Institute of Biophysics
Chinese Academy of Sciences
Beijing 100101

Nanozymes are multi-functional nanomaterials with enzyme-like activity, which rapidly won a place in biomedicine due to their number of nanocatalytic materials types and applications. Yan and Gao first discovered horseradish peroxidase-like activity in ferromagnetic nanoparticles in 2007. With the joint efforts of many scientists, a new concept—nanocatalytic medicine—is emerging. Nanozymes overcome the inherent disadvantages of natural enzymes, such as poor environmental stability, high production costs, difficult storage and so on. Their progress in dentistry is following the advancement of materials science. The oral research and application of nanozymes is becoming a new branch of nanocatalytic medicine. In order to highlight the great contribution of nanozymes facilitating dental health, we first review the overall research progress of multi-functional nanozymes in oral related diseases, including treating dental caries, dental pulp diseases, oral ulcers and peri-implantitis; the monitoring of oral cancer, oral bacteria and ions; and the regeneration of soft and hard tissue. Additionally, we also propose the challenges remaining for nanozymes in terms of their research and application, and mention future concerns. We believe that the new catalytic nanomaterials will play important roles in dentistry in the future.

中文翻译：

纳米酶可口服：纳米催化药物可促进牙齿健康

纳米酶是具有酶样活性的多功能纳米材料，由于其纳米催化材料的类型和应用数量众多，因此迅速在生物医学中占有一席之地。Yan和Gao于2007年首次在铁磁纳米颗粒中发现了类似辣根过氧化物酶的活性。在许多科学家的共同努力下，一个新概念-纳米催化医学-正在出现。纳米酶克服了天然酶的固有缺点，例如环境稳定性差，生产成本高，难以储存等。他们在牙科领域的进步是随着材料科学的发展而发展的。纳米酶的口腔研究与应用正在成为纳米催化医学的一个新分支。为了突出纳米酶在促进牙齿健康方面的巨大贡献，我们首先回顾多功能纳米酶在口腔相关疾病中的整体研究进展，包括治疗龋齿，牙髓疾病，口腔溃疡和种植体周围炎；监测口腔癌，口腔细菌和离子；以及软硬组织的再生。此外，我们还就纳米酶的研究和应用提出了挑战，并提到了未来的担忧。我们相信，新型催化纳米材料将在未来的牙科领域中发挥重要作用。我们还就纳米酶的研究和应用提出了挑战，并提到了未来的担忧。我们相信，新型催化纳米材料将在未来的牙科领域中发挥重要作用。我们还就纳米酶的研究和应用提出了挑战，并提到了未来的担忧。我们相信，新型催化纳米材料将在未来的牙科领域中发挥重要作用。

更新日期：2021-01-11

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