Tannic acid/Mg2+-based versatile coating to manipulate the osteoimmunomodulation of implants,Journal of Materials Chemistry B

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Tannic acid/Mg2+-based versatile coating to manipulate the osteoimmunomodulation of implants
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-23 , DOI: 10.1039/d0tb01577f
Min He _{1,

2,

3,

4,

5} , Xinhui Gao _{1,

2,

3,

4,

5} , Yadi Fan _{6,

7,

8,

9} , Li Xie _{1,

2,

3,

4,

5} , Mo Yang _{6,

7,

8,

9} , Weidong Tian _{1,

2,

3,

4,

5}

Affiliation

Instead of directly stimulating osteogenesis, endowing an implant surface with a favourable osteoimmunomodulatory (OIM) function has emerged as a new effective strategy to enhance osteointegration. Though metal-phenolic coatings have demonstrated to possess an immunomodulatory function, their potential application in manipulating an osteoimmune response has not been well explored. Herein, in order to develop a simple, rapid and universal coating method to impart excellent OIM to hard tissue implants, tannic acid (TA) and Mg²⁺ were selected to form a coating on Ti plate based on metal-phenolic chemistry. Besides its virtues of simplicity, ultrafastness, low-cost, and versatility, another merit for the coating method is that it can easily combine the unique functions of metal ions and phenolic ligands. The chelated Mg²⁺ can not only activate macrophage polarization towards the anti-inflammatory phenotype but also directly stimulate the osteogenic differentiation of bone marrow-derived stem cells (BMSCs). TA motifs rendered the coating with an excellent reactive oxygen species (ROS) scavenging capacity. TA and Mg²⁺ showed synergistic effects on regulating macrophage biological behaviour, suppressing its polarization towards the M1 phenotype, and promoting its polarization towards the M2 phenotype. In vivo histological analysis also demonstrated that the TA/Mg²⁺ coating could effectively inhibit the host response. Finally, the formed osteoimmune environment obviously enhanced the osteogenic differentiation of BMSCs. The above results demonstrated that the designed TA/Mg²⁺ coating not only possessed the function of directly stimulating osteogenesis but also the function of manipulating OIM to a desired one. Hence, it has great potential to be applied on advanced hard tissue implants to enhance osteointegration.

中文翻译：

基于鞣酸/ Mg2 +的多功能涂层，可操纵植入物的骨免疫调节

代替直接刺激成骨作用，赋予植入物表面良好的骨免疫调节（OIM）功能已成为增强骨整合的新有效策略。尽管已证明金属酚醛涂料具有免疫调节功能，但尚未很好地探索其在操纵骨免疫应答中的潜在应用。本文中，为了开发一种简单，快速且通用的涂覆方法，以向硬组织植入物赋予优异的OIM，单宁酸（TA）和Mg ²⁺基于金属-酚化学，选择Ti以在Ti板上形成涂层。除了简单，超牢度，低成本和多功能性外，涂覆方法的另一个优点是它可以轻松地结合金属离子和酚类配体的独特功能。螯合的Mg ²⁺不仅可以激活巨噬细胞向抗炎表型极化，而且可以直接刺激骨髓干细胞（BMSCs）的成骨分化。TA图案使涂层具有出色的活性氧清除能力。TA和Mg ²⁺在调节巨噬细胞生物学行为，抑制其向M1表型的极化并促进其向M2表型的极化方面显示出协同作用。体内组织学分析还表明，TA / Mg ²⁺涂层可以有效抑制宿主反应。最后，形成的骨免疫环境明显增强了骨髓间充质干细胞的成骨分化。以上结果表明，设计的TA / Mg ²⁺涂层不仅具有直接刺激成骨的功能，而且还具有将OIM操纵成所需的功能。因此，它具有巨大的潜力可应用于先进的硬组织植入物中，以增强骨整合。

更新日期：2021-01-11

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