Engineered protein cages for selective heparin encapsulation,Journal of Materials Chemistry B

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Engineered protein cages for selective heparin encapsulation
Journal of Materials Chemistry B ( IF 6.1 ) Pub Date : 2020-12-17 , DOI: 10.1039/d0tb02541k
Salla Välimäki _{1,

2,

3,

4} , Qing Liu _{1,

2,

3,

4} , Lise Schoonen _{5,

6,

7,

8} , Daan F. M. Vervoort _{8,

9,

10,

11,

12} , Nonappa _{2,

3,

4,

13,

14} , Veikko Linko _{1,

2,

3,

4,

13} , Roeland J. M. Nolte _{5,

6,

7,

8} , Jan C. M. van Hest _{5,

6,

7,

8,

9} , Mauri A. Kostiainen _{1,

2,

3,

4,

13}

Affiliation

A heparin-specific binding peptide was conjugated to a cowpea chlorotic mottle virus (CCMV) capsid protein, which was subsequently allowed to encapsulate heparin and form capsid-like protein cages. The encapsulation is specific and the capsid-heparin assemblies display negligible hemolytic activity, indicating proper blood compatibility and promising possibilities for heparin antidote applications.

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