The effect of grinding on the pharmaceutical properties of matrix tablets consisting of ground glutinous rice starch (GRS) and theophylline (TH) was predicted by near infrared (NIR) spectroscopy. Ground GRS samples were prepared by grinding GRS in a planetary ball mill for 0-120 min, measured by X-ray diffractometry (XRD) and NIR, and then evaluated for crystallinity (%XRD) based on XRD profiles. Tablets containing TH (5 w/w%), ground GRS (94 w/w%), and magnesium stearate (1 w/w%) were formed by compression. Gel-forming and drug-release processes of the tablets were measured using a dissolution instrument with X-ray computed tomography (XCT). Swelling ratio (SWE) and mean drug-release time (MDT) were evaluated based on XCT and drug-release profiles, respectively. Calibration models for predicting percent %XRD, MDT, and SWE were constructed based on the NIR of ground GRS using partial least-squares. The results indicated the possibility of controlling the pharmaceutical properties of matrix tablets by altering the pre-gelatinization of GRS based on changes in their NIR spectra during the milling process.

通过近红外（NIR）光谱预测了研磨对由糯米淀粉粉（GRS）和茶碱（TH）组成的基质片剂的药理作用的影响。研磨后的GRS样品是通过在行星式球磨机中将GRS研磨0-120分钟，通过X射线衍射（XRD）和NIR测量而制备的，然后根据XRD曲线评估结晶度（％XRD）。通过压制形成含有TH（5 w / w％），研磨的GRS（94 w / w％）和硬脂酸镁（1 w / w％）的片剂。使用具有X射线计算机断层扫描（XCT）的溶出度仪测量片剂的凝胶形成和药物释放过程。分别根据XCT和药物释放曲线评估溶胀率（SWE）和平均药物释放时间（MDT）。用于预测％XRD，MDT，SWE和SWE是基于地面GRS的近红外光谱，使用偏最小二乘法构造的。结果表明，通过在研磨过程中通过改变GRS的NIR光谱来改变GRS的预糊化，可以控制其药物特性。