The circadian field has come a long way since I started as a postdoctoral fellow ~30 years ago. At the time, the only known animal clock gene was period, so I had the privilege of witnessing, and participating in, the molecular revolution that took us from the discovery of the circadian clock mechanism to the identification of pathways that link clocks to behavior and physiology. This lecture highlights my role and perspective in these developments, and also demonstrates how the successful use of Drosophila for studies of circadian rhythms inspired us to develop a fly model for sleep. I also touch upon my experiences as a non-white immigrant woman navigating my way through the US science and education system, and hope my story will be of interest to some.

自从我大约 30 年前开始担任博士后研究员以来，昼夜节律领域已经取得了长足的进步。当时，唯一已知的动物时钟基因是period，所以我有幸见证并参与了分子革命，这场革命将我们从发现生物钟机制到识别将时钟与行为和行为联系起来的途径生理。本次讲座突出了我在这些发展中的作用和观点，并展示了成功使用果蝇研究昼夜节律如何启发我们开发睡眠飞行模型。我还谈到了我作为一名非白人移民女性在美国科学和教育系统中的经历，并希望我的故事会引起一些人的兴趣。