Background. Kawasaki disease (KD) is a self-limited vasculitis with unknown etiologies, and coronary artery lesions (CALs) are the most common and serious complications. Retinol-binding protein 4 (RBP4) has been confirmed effects on vasodilation, platelet activation inhibition, and cardiovascular diseases by researches. Therefore, this study was aimed at investigating the relationship between RBP4 and inflammation as well as thrombogenesis in children with KD. Methods. 79 subjects were from 62 children with KD and 17 healthy controls (HCs). The KD group was divided into KD with CALs (KD-CALs) and KD without CALs (KD-NCALs), and the serum RBP4 levels were measured by enzyme-linked immunosorbent assay (ELISA). Results. Compared with the HC group, serum RBP4 levels in the KD group were significantly decreased (). RBP4, hemoglobin (Hb), and mean platelet volume (MPV) levels were higher, while platelet counts (Plt) and thrombin time (TT) levels were lower in the KD-NCALs group than in the KD-CALs group (). RBP4 had positive correlation with time point of intravenous immunoglobulin (IVIG), Hb, and percentage of leukomonocytes (L%) and negative correlation with the percentage of neutrophils (N%), MPV, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR), prothrombin time (PT), fibrinogen (Fbg), and D-dimer (DD) in the KD group; RBP4 had positive correlation with the time point of IVIG and L% and negative correlation with N%, MPV, and NLR in the KD-NCALs group; and RBP4 had positive correlation with Hb and L% and negative correlation with N%, CRP, NLR, and PT in the KD-CALs group (). Multiple linear regression analysis confirmed that Hb and CRP in the KD group, MPV and N% in the KD-NCALs group, and PT and CRP in the KD-CALs group were independent predictors of RBP4 (). Conclusion. Lower RBP4 was observed in the KD group than in the HC group, and RBP4 had associations with markers of inflammation and thrombogenesis in children with KD.

中文翻译：

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川崎病患儿视黄醇结合蛋白 4 与炎症和血栓形成标志物的关系

背景。川崎病（KD）是一种病因不明的自限性血管炎，冠状动脉病变（CALs）是最常见和最严重的并发症。视黄醇结合蛋白 4 (RBP4) 已被研究证实对血管舒张、血小板活化抑制和心血管疾病有作用。因此，本研究旨在调查 RBP4 与 KD 儿童炎症和血栓形成之间的关系。方法。79 名受试者来自 62 名 KD 患儿和 17 名健康对照 (HC)。KD组分为有CALs的KD（KD-CALs）和无CALs的KD（KD-NCALs），采用酶联免疫吸附试验（ELISA）测定血清RBP4水平。结果. 与 HC 组相比，KD 组血清 RBP4 水平显着降低（）。KD-NCALs 组的 RBP4、血红蛋白 (Hb) 和平均血小板体积 (MPV) 水平较高，而 KD-NCALs 组的血小板计数 (Plt) 和凝血酶时间 (TT) 水平低于 KD-CALs 组。）。RBP4与静脉注射免疫球蛋白时间点（IVIG）、Hb、白单核细胞百分比（L%）呈正相关，与中性粒细胞百分比（N%）、MPV、C反应蛋白（CRP）、中性粒细胞-to呈负相关-KD组中的淋巴细胞比率（NLR）、凝血酶原时间（PT）、纤维蛋白原（Fbg）和D-二聚体（DD）；KD-NCALs组RBP4与IVIG时间点、L%呈正相关，与N%、MPV、NLR呈负相关；KD-CALs组RBP4与Hb、L%呈正相关，与N%、CRP、NLR、PT呈负相关（）。多元线性回归分析证实 KD 组的 Hb 和 CRP、KD-NCALs 组的 MPV 和 N%、KD-CALs 组的 PT 和 CRP 是 RBP4 的独立预测因子。）。 结论。在 KD 组中观察到的 RBP4 低于 HC 组，并且 RBP4 与 KD 儿童的炎症和血栓形成标志物相关。