Dendritic Macromolecular Architectures: Dendrimer-Based Polyion Complex Micelles,Biomacromolecules

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Dendritic Macromolecular Architectures: Dendrimer-Based Polyion Complex Micelles
Biomacromolecules ( IF 5.5 ) Pub Date : 2021-01-11 , DOI: 10.1021/acs.biomac.0c01645
Serge Mignani _{1,

2} , Xiangyang Shi ₃ , Maria Zablocka ₄ , Jean-Pierre Majoral _{5,

6}

Affiliation

Polymeric micelles are nanoassemblies that are formed by spontaneous arrangement of amphiphilic block copolymers in aqueous solutions at critical micelle concentration (CMC). They represent an effective system for drug delivery of, for instance, poorly water-soluble anticancer drugs. Then, the development of polyion complexes (PICs) were emphasized. The morphology of these complexes depends on the topology of the polyelectrolytes used and the way they are assembled. For instance, ionic-hydrophilic block copolymers have been used for the preparation of PIC micelles. The main limitation in the use of PIC micelles is their potential instability during the self-assembly/disassembly processes, influenced by several parameters, such as polyelectrolyte concentration, deionization associated with pH, ionic strength due to salt medium effects, mixing ratio, and PIC particle cross-linking. To overcome these issues, the preparation of stable PIC micelles by increasing the rigidity of their dendritic architecture by the introduction of dendrimers and controlling their number within micelle scaffold was highlighted. In this original concise Review, we will describe the preparation, molecular characteristics, and pharmacological profile of these stable nanoassemblies.

中文翻译：

树枝状大分子体系结构：基于树枝状大分子的聚离子复合物胶束

聚合物胶束是通过两亲性嵌段共聚物在临界胶束浓度（CMC）下自发地在水溶液中排列而形成的纳米组件。它们代表了有效的药物递送系统，例如水溶性差的抗癌药物。然后，强调了聚离子复合物（PIC）的发展。这些复合物的形态取决于所用聚电解质的拓扑结构及其组装方式。例如，离子亲水嵌段共聚物已用于制备PIC胶束。使用PIC胶束的主要限制是它们在自组装/拆卸过程中的潜在不稳定性，受多个参数的影响，例如聚电解质的浓度，与pH值相关的去离子，由于盐介质效应，混合比，和PIC粒子交联。为了克服这些问题，强调了通过引入树枝状聚合物并通过控制其在胶束支架中的数目来增加其树枝状结构的刚性来制备稳定的PIC胶束。在这份原始的简明综述中，我们将描述这些稳定的纳米组件的制备，分子特征和药理学特征。

更新日期：2021-02-08

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