The effects of acute consumption of L-Arginine (L-Arg) in healthy young individuals are not clearly defined, and no studies on the effects of L-Arg in individuals with abnormal body mass index undertaking strenuous exercise exist. Thus, we examined whether supplementation with L-Arg diminishes cardiopulmonary exercise testing responses, such as ventilation (VE), VE/VCO₂, oxygen uptake (VO₂), and heart rate, in response to an acute session of high-intensity interval exercise (HIIE) in overweight men. A double-blind, randomized crossover design was used to study 30 overweight men (age, 26.5 ± 2.2 years; body weight, 88.2 ± 5.3 kilogram; body mass index, 28.0 ± 1.4 kg/m²). Participants first completed a ramped-treadmill exercise protocol to determine VO₂max velocity (vVO₂max), after which they participated in two sessions of HIIE. Participants were randomly assigned to receive either 6 g of L-Arg or placebo supplements. The HIIE treadmill running protocol consisted of 12 trials, including exercise at 100% of vVO₂max for 1 min interspersed with recovery intervals of 40% of vVO₂max for 2 min. Measurements of VO₂ (ml·kg⁻¹·min⁻¹), VE (L/min), heart rate (beat per min), and VE/VCO₂ were obtained. Supplementation with L-Arg significantly decreased all cardiorespiratory responses during HIIE (placebo+HIIE vs. L-Arg+HIIE for each measurement: VE [80.9 ± 4.3 L/min vs. 74.6 ± 3.5 L/min, p < .05, ES = 1.61], VE/VCO₂ [26.4 ± 1.3 vs. 24.4 ± 1.0, p < .05, ES = 1.8], VO₂ [26.4 ± 0.8 ml·kg⁻¹·min⁻¹ vs. 24.4 ± 0.9 ml·kg⁻¹·min⁻¹, p < .05, ES = 2.2], and heart rate [159.7 ± 6.3 beats/min vs. 155.0 ± 3.7 beats/min, p < .05, d = 0.89]). The authors conclude consuming L-Arg before HIIE can alleviate the excessive physiological strain resulting from HIIE and help to increase exercise tolerance in participants with a higher body mass index who may need to exercise on a regular basis for extended periods to improve their health.

急性消耗L-精氨酸 ( L - Arg ) 对健康年轻人的影响尚不明确，也没有关于L- Arg 对体重指数异常的个体进行剧烈运动的影响的研究。因此，我们检查了补充L- Arg是否会降低心肺运动测试反应，例如通气 (VE)、VE/VCO ₂、摄氧量 (VO ₂ ) 和心率，以响应高强度间歇的急性期超重男性的运动（HIIE）。采用双盲、随机交叉设计研究 30 名超重男性（年龄 26.5 ± 2.2 岁；体重 88.2 ± 5.3 公斤；体重指数 28.0 ± 1.4 kg/m ²）。参与者首先完成了斜坡跑步机锻炼方案以确定 VO ₂最大速度 (vVO ₂ max)，之后他们参加了两次 HIIE。参与者被随机分配接受 6 g L- Arg 或安慰剂补充剂。HIIE 跑步机跑步方案由 12 项试验组成，包括以 100% 的最大vVO ₂锻炼1 分钟，以及以 40% 的最大vVO ₂进行 2 分钟的恢复间隔。获得VO ₂ (ml·kg ^-1 ·min ^-1 )、VE (L/min)、心率(每分钟跳动)和VE/VCO ₂的测量值。补充L-Arg 显着降低 HIIE 期间的所有心肺反应（安慰剂+HIIE vs. L -Arg+HIIE 每次测量：VE [80.9 ± 4.3 L/min vs. 74.6 ± 3.5 L/min, p  < .05, ES = 1.61] , VE/VCO ₂ [26.4 ± 1.3 vs. 24.4 ± 1.0, p  < .05, ES = 1.8], VO ₂ [26.4 ± 0.8 ml·kg ^-1 ·min ^-1 vs. 24.4 ± 0.9 ml·kg ^-1 ·min ^-1 , p  < .05, ES = 2.2] 和心率 [159.7 ± 6.3 次/分钟 vs. 155.0 ± 3.7 次/分钟, p  < .05, d  = 0.89])。作者总结消费L- HIIE之前的Arg可以缓解HIIE造成的过度生理压力，并有助于提高体重指数较高的参与者的运动耐力，这些参与者可能需要长时间定期锻炼以改善健康。