Aspergillus fumigatus (Af) frequently colonizes the respiratory tract of patients with cystic fibrosis (CF). Af is associated with loss of pulmonary function and allergic bronchopulmonary aspergillosis (ABPA), a hypersensitivity fungal lung disease. Environmental factors have impact on CF patients’ lung function variation. The aim of this nationwide questionnaire survey was to investigate the amount of CF patients with frequent pet contact including pet species and to examine the potential impact of frequent pet contact on the occurrence of Af colonization and ABPA diagnosis in these patients. The survey was carried out in 31 German CF centers in 2018. A total of 1232 who completed the surveys were included, and statistical analysis was performed by chi-squared test. Within the study cohort 49.8% of subjects (n = 614; CF patients < 18years: 49.4%, n = 234; ≥ 18years: 50.1%, n = 380) reported frequent contact to pets, of which 60.7% reported frequent contact to dogs, 42.3% to cats and other animals. Of those with frequent pet contact, 71.8% (n = 441) had contact to one pet or more pets from the same family. Af colonization was not significantly associated with frequent pet contact. ABPA diagnosis was documented in 16.7% (n = 206) of all included CF patients and was significantly associated with frequent pet contact (18.9%, n = 116, p = 0.042), confirming previous single center examinations. Particularly, patients with frequent contact to dogs showed an increased ABPA prevalence of 21.3%. Frequent pet contact might be a risk factor for ABPA. CF patients who are sensitized to Af should be informed about the increased risk to develop an ABPA by frequent pet contact. Patients with recurrent onset of ABPA should be evaluated in terms of frequent pet contact.

烟曲霉 （f）经常在囊性纤维化（CF）患者的呼吸道中定植。 f与肺功能丧失和过敏性支气管肺曲霉病（ABPA）（一种真菌性肺过敏性疾病）有关。环境因素影响CF患者的肺功能变化。这项全国性问卷调查的目的是调查与宠物频繁接触的CF患者（包括宠物物种）的数量，并调查频繁接触宠物对发生CF的潜在影响。f这些患者中的细菌定植和ABPA诊断。该调查于2018年在31个德国CF中心进行。总共包括1232名完成调查的人，并通过卡方检验进行了统计分析。在研究队列中，有49.8％的受试者（n = 614； CF患者<18岁：49.4％，n = 234；≥18岁：50.1％，n = 380）报告了与宠物的频繁接触，其中60.7％的受试者与宠物的频繁接触，其中猫和其他动物占42.3％。在那些频繁接触宠物的人中，有71.8％（n = 441）与同一家庭的一只或多只宠物接触过。f移殖与频繁接触宠物没有显着相关。在所有纳入的CF患者中，有16.7％（n = 206）记录了ABPA诊断，并且与频繁的宠物接触有显着相关性（18.9％，n = 116，p = 0.042），从而证实了先前的单中心检查。特别是，经常与狗接触的患者显示ABPA患病率增加了21.3％。经常接触宠物可能是ABPA的危险因素。对以下药物敏感的CF患者f应被告知经常与宠物接触会增加患ABPA的风险。ABPA反复发作的患者应根据经常接触宠物进行评估。