In this work, the mechanical and bio-functional behavior of a TiNbTa alloy is evaluated as a potential prosthetic biomaterial used for cortical bone replacement. The results are compared with the reference Ti c.p. used as biomaterials for bone-replacement implants. The estimated mechanical behavior for TiNbTa foams was also compared with the experimental Ti c.p. foams fabricated by the authors in previous studies. A TiNbTa alloy with a 20–30% porosity could be a candidate for the replacement of cortical bone, while levels of 80% would allow the manufacture of implants for the replacement of trabecular bone tissue. Regarding biocompatibility, in vitro TiNbTa, cellular responses (osteoblast adhesion and proliferation) were compared with cell growth in Ti c.p. samples. Cell adhesion (presence of filopodia) and propagation were promoted. The TiNbTa samples had a bioactive response similar to that of Ti c.p. However, TiNbTa samples show a better balance of bio-functional behavior (promoting osseointegration) and biomechanical behavior (solving the stress-shielding phenomenon and guaranteeing mechanical resistance).

中文翻译：

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刚度合适的TiNbTa合金的生物相容性和细胞行为替代骨组织

在这项工作中，TiNbTa合金的机械和生物功能行为被评估为用于皮层骨置换的潜在义肢生物材料。将结果与用作骨替代植入物的生物材料的参考Ti cp进行比较。作者还将TiNbTa泡沫的估计机械性能与作者在先前研究中制造的实验性Ti cp泡沫进行了比较。孔隙度为20％至30％的TiNbTa合金可以替代皮质骨，而80％的含量可以制造用于替代小梁骨组织的植入物。关于生物相容性，将体外TiNbTa，细胞反应（成骨细胞粘附和增殖）与Ti cp样品中的细胞生长进行了比较。促进细胞粘附（存在丝状伪足）和繁殖。