Abstract

Roots of Argyreia nervosa (Burm. f.) Bojer are used as aphrodisiac and spermatogenic in the treatment of male infertility. The present studies included in vivo assessment of alkaloidal fraction in male rats on testosterone synthesis in leydig cells. Studies included oral administration of doses of alkaloidal fraction (10, 25 and 50 mg/kg) to rats. Results showed 100% and 146.7% increment in serum testosterone and serum cholesterol at 50 mg/kg dose level, respectively. At the same dose, 135.29% increase in mounting frequency and 357.14% increase in intromission frequency were also observed. Moreover, mount latency and intromission latency were reduced by 32% and 15.88%. Also, there was significant increase in the weight of testes, prostate, seminal vesicle and epididymis. There was 30.26% rise in sperm concentration in treated animals. We conclude that the alkaloidal fraction up-regulated testosterone biosynthesis in leydig cells and it could be responsible for the aphrodisiac and spermatogenic effect.

摘要

根美丽银背藤（Burm。F。）蛾用作壮阳药和男性不育症的治疗精子发生。本研究包括体内对雄性大鼠生物碱成分对leydig细胞睾丸激素合成的影响 研究包括给大鼠口服生物碱部分剂量（10、25和50 mg / kg）。结果显示，在50 mg / kg剂量水平下，血清睾丸激素和血清胆固醇分别增加100％和146.7％。在相同剂量下，还观察到安装频率增加135.29％，引入频率增加357.14％。此外，安装延迟和引入延迟分别减少了32％和15.88％。同样，睾丸，前列腺，精囊和附睾的重量也显着增加。治疗动物的精子浓度增加了30.26％。我们得出的结论是，生物碱成分上调了leydig细胞中睾丸激素的生物合成，这可能是壮阳药和生精作用的原因。