ABSTRACT

Several articles have shown a positive effect of Inulin Type-Carbohydrates (ITC) on blood pressure (BP); nevertheless, these findings are controversial. Therefore, a systematic review and meta-analysis of randomized-controlled trials (RCTs) proposed to investigate the effects of ITC supplementation on BP. An online search was carried out in PubMed, Scopus, ISI Web of Science, Cochrane library, and Google Scholar up to December 2019. Weighted Mean difference (WMD) with 95% confidence intervals (CIs) were calculated using a Random-effects model. Statistical heterogeneity was evaluated using Q tests and the I2 statistic. Subgroup analysis was accomplished based on the clinical characteristics (Gender and health status) of the subjects to exclude heterogeneity. We used Begg’s rank correlation and Egger’s regression asymmetry tests to assess publication bias. The proportion of each study in the overall effect was evaluated by sensitivity analysis. The current meta-analysis of five trials (with six arms) RCTs with 233 participants indicated that supplementation with ITC cannot reduce both systolic BP (WMD: −5.83 mmHg; 95% CI: −12.49, 0.82, P = .086) and diastolic BP (WMD: −2.62 mmHg, 95% CI: −6.15 to 0.92, P = .147). Subgroup analysis based on gender revealed meaningful effects of ITC on SBP in subsets of females. Further well-designed RCTs in subjects with hypertension are required for a more robust assessment of the anti-hypertensive properties of this type of prebiotics.

摘要

几篇文章显示了菊粉型碳水化合物（ITC）对血压（BP）的积极作用；但是，这些发现是有争议的。因此，建议对随机对照试验（RCT）进行系统的回顾和荟萃分析，以研究补充ITC对BP的影响。截至2019年12月，在PubMed，Scopus，ISI Web of Science，Cochrane图书馆和Google Scholar中进行了在线搜索。使用随机效应模型计算了具有95％置信区间（CI）的加权均值差（WMD）。使用Q检验和I2统计量评估统计异质性。根据受试者的临床特征（性别和健康状况）完成亚组分析，以排除异质性。我们使用了Begg的秩相关和Egger的回归不对称检验来评估出版偏倚。通过敏感性分析评估每个研究在总体效果中的比例。目前对233名参与者进行的5项试验（6组）RCT的荟萃分析表明，补充ITC不能同时降低两种收缩压（WMD：−5.83 mmHg； 95％CI：−12.49，0.82，P = .086）和舒张压BP（WMD：-2.62 mmHg，95％CI：-6.15至0.92，P = .147）。基于性别的亚组分析显示，ITC对女性亚群中的SBP具有有意义的影响。为了更可靠地评估这类益生元的抗高血压特性，需要对高血压患者进行进一步设计良好的RCT。