Abstract

Introduction

The COVID-19 pandemic is still escalating and has shaped an extraordinary and pressing need for rapid diagnostics with high sensitivity and specificity. Prompt diagnosis is the key to mitigate this situation. As several diagnostic tools for COVID-19 are already available and still others are under development, mandating a comprehensive review of the efficacy of existing tools and evaluate the potential of others.

Areas Covered

Currently explored platforms for SARS-CoV-2 diagnostics and surveillance centered on qRT-PCR, RT-PCR, CRISPR, microarray, LAMP, lateral flow immunoassays, proteomics-based approaches, and radiological scans are overviewed and summarized in this review along with their advantages and downsides. A narrative literature review was carried out by accessing the freely available online databases to encapsulate the developments in medical diagnostics.

Expert Opinion

An ideal detection method should be sensitive, specific, rapid, cost-effective, and should allow early diagnosis of the infection as near as possible to the point of care that could alter the current situation for the better. Medical diagnostics is a highly dynamic field as no diagnostic method available for SARS-CoV-2 detection offers a perfect solution and requires more attention and continuous R&D to challenge the present-day pandemic situation

中文翻译：

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诊断COVID-19的最新进展：鸟瞰图

摘要

介绍

COVID-19大流行仍在升级，并形成了对具有高灵敏度和特异性的快速诊断的迫切需求。及时诊断是缓解这种情况的关键。由于已经有了几种针对COVID-19的诊断工具，并且仍在开发中，因此，必须对现有工具的功效进行全面评估，并评估其他工具的潜力。

覆盖区域

本文综述了目前针对SARS-CoV-2诊断和监测的平台，这些平台主要围绕qRT-PCR，RT-PCR，CRISPR，微阵列，LAMP，侧向流免疫测定，基于蛋白质组学的方法和放射学扫描，以及它们的概述。优点和缺点。通过访问免费提供的在线数据库对叙事文献进行回顾，以概括医学诊断学的发展。

专家意见

理想的检测方法应灵敏，特异，快速，具有成本效益，并应尽可能早于可能会改变当前状况的护理点对感染进行早期诊断。医疗诊断是一个高度动态的领域，因为没有可用于SARS-CoV-2检测的诊断方法提供了完美的解决方案，需要更多的关注和不断的研发以挑战当今的大流行情况