ABSTRACT

While photochemical oxidants (O_x = O₃+ NO₂) are known to increase asthma flare-ups, there is a paucity of studies of the Japanese population, especially for Tokyo residents. We used data on asthma cases (n = 7,455) from ambulance dispatches in Tokyo, 2015–2016. Variables included date and time of incidence, age, sex, occurrence location at the ward (ku) level, and the symptom/cause of dispatch as recorded by paramedics. O_x data were obtained from the nearest air quality monitoring station to the occurrence location, then linked them with the outcomes based on occurrence date. We directly incorporated a distributed lag model into a bi-directional case-crossover study design controlling for ambient temperature and day of week. A 10-ppb increase in O_x for lag days 0–3 was associated with a 5.51% (95% CI: 0.13 to 11.18) increase in ambulance dispatches related to asthma. The association was strongest on lag day 1 (4.67%, 95% CI: 0.51 to 9.00). Exposure to high levels of O_x was associated with increased ambulance dispatches related to asthma exacerbations in Tokyo, Japan.

摘要

虽然光化学氧化剂（O _x  = O ₃ + NO ₂）会增加哮喘发作，但对日本人口的研究却很少，尤其是对东京居民而言。我们使用了2015–2016年东京急救人员派遣的哮喘病例（n = 7,455）数据。变量包括发病日期和时间，年龄，性别，病房（ku）级别的发生位置，以及医护人员记录的分派症状/原因。Ø _X从最近的空气质量监测站到发生地点获取数据，然后根据发生日期将它们与结果关联起来。我们将分布式滞后模型直接合并到双向病例交叉研究设计中，以控制环境温度和星期几。在O 10-ppb的增加_X为滞后0-3天用5.51％（95％CI：0.13〜11.18）在与哮喘有关救护车分派增加。关联在滞后第1天最强（4.67％，95％CI：0.51至9.00）。暴露于高浓度的Ø _X与增加有关在日本东京哮喘加重救护车调度有关。