Cover illustration Structurally inherent self‐regulation of AID. The top bottleneck represents substrate selection wherein the vast majority of AID complexes with ssDNA or DNA/RNA are catalytically non‐productive and the minor proportion of substrates that fit into the ssDNA or RNA binding grooves are recognized by a plastic combination of two or three of the 5 substrate binding grooves. The second bottleneck is that even after the formation of the rare AID:substrate complexes that position a dC proximal to the catalytic pocket, AID’s catalytic pocket has a higher probability of being closed, a phenomenon termed the “Schrödinger’s CATalytic pocket. The cover image refers to the article “Structural plasticity of substrate selection by activation‐induced cytidine deaminase as a regulator of its genome‐wide mutagenic activity” by J. King and M. Larijani (pp. 3–13).

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封面

封面插图AID在结构上固有的自我调节。最上层的瓶颈代表了底物的选择，其中大多数与ssDNA或DNA / RNA的AID配合物是催化性非生产性的，而适合ssDNA或RNA结合槽的底物的较小部分被两个或三个的塑料结合识别5个基板装订槽。第二个瓶颈是，即使在稀有的AID：底物络合物形成之后，将dC放置在催化腔附近，AID的催化腔仍被封闭的可能性更高，这种现象被称为“薛定ding的CATalytic腔”。封面图片是J. King和M. Larijani撰写的文章“通过激活诱导的胞苷脱氨酶作为其全基因组诱变活性的调节剂来选择底物的结构可塑性”（第3-13页）。