Synthesis of Fully Substituted Oxazoles via an NFSI/KF‐Mediated Double Bond Cleavage‐Rearrangement Cascade,Asian Journal of Organic Chemistry

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Synthesis of Fully Substituted Oxazoles via an NFSI/KF‐Mediated Double Bond Cleavage‐Rearrangement Cascade
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2021-01-11 , DOI: 10.1002/ajoc.202000627
Dan Wu ₁ , Yi Lu ₁ , Wen-Juan Hao ₂ , Shu-Jiang Tu ₁ , Bo Jiang ₃

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An NFSI/KF‐mediated scission/recombination of C−C double bonds for [4+1] annulation is reported, leading to the efficient synthesis of a wide range of fully substituted oxazoles in good to excellent yields under mild redox‐neutral conditions. This methodology might open a new entry for the preparation of structurally applicable heterocyclic systems in a highly functional‐group‐compatible manner.

中文翻译：

通过NFSI / KF介导的双键裂解-重排级联反应合成全取代的恶唑

据报道，NFSI / KF介导的C-C双键断裂/重组可实现[4 + 1]环化，可在温和的氧化还原中性条件下有效合成各种完全取代的恶唑，收率良好至优异。这种方法学可能为以高度功能基团兼容的方式制备结构上适用的杂环系统开辟新的道路。

更新日期：2021-03-11

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