[5+2] Cyclization of N,N′‐Cyclic Azomethine Imines with 1,3,5‐Triazines: An Efficient Protocol for the Synthesis of Tetrazepine Derivatives,Asian Journal of Organic Chemistry

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[5+2] Cyclization of N,N′‐Cyclic Azomethine Imines with 1,3,5‐Triazines: An Efficient Protocol for the Synthesis of Tetrazepine Derivatives
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2021-01-11 , DOI: 10.1002/ajoc.202000705
Rongxiang Chen ₁ , Qingling Liu ₁ , Kai-Kai Wang ₂ , Yonghua Qi ₁ , Yong Zhou ₃ , An-an Zhang ₄ , Tuanjie Meng ₄ , Lantao Liu ₄

Affiliation

An unprecedented formal [5+2] cyclization of N,N′‐cyclic azomethine imines with triazines has been realized, which provides a facile access to biologically important 1,2,4,6‐tetrazepine frameworks with overall high yields (up to 98% yield). This methodology is distinguished by not involving a metal catalyst, readily available starting materials, and operational simplicity, which involves the reassembly of two C−N bonds.

中文翻译：

[5 + 2]用1,3,5-三嗪将N，N'-环甲亚胺亚胺环化：合成四氮杂衍生物的有效方案

N，N'-环偶氮甲亚胺与三嗪的史无前例的正式[5 + 2]环化反应已经实现，这为生物重要的1,2,4,6-四氮杂骨架提供了便捷的途径，总体收率很高（高达98 ％屈服）。该方法的特点是不涉及金属催化剂，易于获得的起始原料以及操作简便（涉及两个CN键的重新组装）。

更新日期：2021-02-10

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