Ruthenium‐Catalyzed Synthesis of α‐Alkylated Ketones and Quinolines in an Aqueous Medium via a Hydrogen‐Borrowing Strategy Using Ketones and Alcohols,Asian Journal of Organic Chemistry

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Ruthenium‐Catalyzed Synthesis of α‐Alkylated Ketones and Quinolines in an Aqueous Medium via a Hydrogen‐Borrowing Strategy Using Ketones and Alcohols
Asian Journal of Organic Chemistry ( IF 2.8 ) Pub Date : 2021-01-11 , DOI: 10.1002/ajoc.202000686
Ashutosh Verma ₁ , Susanta Hazra ₁ , Pritam Dolui ₁ , Anil Jacob Elias ₂

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Herein, we report a simple, efficient, and sustainable method for the synthesis of α‐alkylated ketones and quinolines using a hydrogen‐borrowing strategy, which has emerged as a greener alternative in organic transformation reactions. Synthesis of a range of α‐alkylated ketones and quinoline derivatives was achieved by using the water‐soluble [Ru(8‐AQ)Cl(p‐cym.)]⁺Cl⁻ [Ru]‐1 (AQ=aminoquinoline) catalyst with water as the reaction medium. By adopting this strategy, we have synthesized α‐alkylated ketones and quinolines using ketones or secondary alcohols as starting materials and the primary alcohol as a green and naturally abundant alkylating agent.

中文翻译：

钌通过酮和醇的氢借入策略在水介质中钌催化合成α-烷基化的酮和喹啉

本文中，我们报告了一种利用氢借用策略合成α-烷基化的酮和喹啉的简单，有效和可持续的方法，该方法已成为有机转化反应中的一种更绿色的替代方法。的范围内α -烷基化的酮和喹啉衍生物的合成是通过使用水溶性实现的[Ru（8-AQ）氯（对- CYM。）] ⁺氯^- -1（AQ =氨基喹啉）的[Ru]催化剂与水作为反应介质。通过采用这种策略，我们以酮或仲醇为原料，伯醇为绿色和天然丰富的烷基化剂，合成了α-烷基化的酮和喹啉。

更新日期：2021-03-11

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