Emerging evidence has indicated that long noncoding RNAs (lncRNAs) are involved in various pathophysiological processes of disease, such as cancer occurrence, viral invasion, and inflammatory damage. The main inflammatory body component, nod-like receptor protein 3 (NLRP3), is the trigger point of inflammatory reactions and inflammation-related diseases and coordinates the body's response to inflammation. At present, increasing evidence shows that the interaction of lncRNAs and the NLRP3 inflammasome plays an important role in the inflammatory response and different diseases. This may be involved in the development and progression of various diseases by activating signalling pathways and a variety of molecular regulatory mechanisms—this article reviews progress in research on the relationship between lncRNAs and the NLRP3 inflammasome under different conditions.

越来越多的证据表明，长的非编码RNA（lncRNA）参与了疾病的各种病理生理过程，例如癌症的发生，病毒的入侵和炎性损害。炎症的主要组成部分，即点头样受体蛋白3（NLRP3），是炎症反应和与炎症相关的疾病的触发点，并协调人体对炎症的反应。目前，越来越多的证据表明，lncRNA与NLRP3炎性小体的相互作用在炎症反应和各种疾病中起重要作用。