Antibiotic resistance is acquired in response to antibiotic therapy by activating SOS-depended mutagenesis and horizontal gene transfer pathways. Compounds able to inhibit SOS response are extremely important to develop new combinatorial strategies aimed to block mutagenesis. The regulators of homologous recombination involved in the processes of DNA repair should be considered as potential targets for blocking. This review highlights the current knowledge of the protein targets for the evolution of antibiotic resistance and the inhibitory effects of some new compounds on this pathway.

中文翻译：

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通过SOS反应抑制靶向抗生素耐药性的演变

通过激活依赖SOS的诱变和水平基因转移途径，对抗生素治疗产生抗药性。能够抑制SOS反应的化合物对于开发旨在阻止诱变的新组合策略极为重要。DNA修复过程中涉及的同源重组调节剂应被视为潜在的阻断靶标。这篇综述着重介绍了目前抗生素抗性进化目标蛋白的知识以及一些新化合物对该途径的抑制作用。