Toll-like receptors (TLRs) are a class of proteins (patterns recognition receptors-PRRs) capable of recognizing molecules frequently found in pathogens (that are so-called pathogen-associated molecular patterns-PAMPs), they play a key role in the initiation of innate immune response by detecting PAMPs. Our findings show that the functional effects of TLRs co-stimulation on megakaryocytopoiesis. A single cell may receive multiple signal inputs and we consider that multiple TLRs are likely triggered during infection by multiple PAMPs that, in turn, might be involved in infection driven megakaryocytopoiesis, and the present study provide the evidence for the megakaryocytic effects of TLRs co-stimulation.

Toll 样受体 (TLRs) 是一类能够识别病原体中常见分子（即所谓的病原体相关分子模式-PAMPs）的蛋白质（模式识别受体-PRRs），它们在启动过程中起关键作用。通过检测 PAMPs 的先天免疫反应。我们的研究结果表明，TLR 共刺激对巨核细胞生成的功能影响。单个细胞可能接收多个信号输入，我们认为多个 TLR 在感染期间可能被多个 PAMP 触发，而这些 PAMP 反过来可能参与感染驱动的巨核细胞生成，本研究为 TLR 共同作用的巨核细胞效应提供了证据。刺激。