The coaxial electrospinning for producing core-shell nanofibers due to control the release profile of drug by the shell layer has been developed. N-carboxymethyl chitosan (CMC)-polyvinyl alcohol (core)/poly(ε-caprolactone) (PCL) (shell) nanofibers were produced via coaxial electrospinning. Doxorubicin (DOX) and nickel ferrite nanoparticles were incorporated into the nanofibers for controlled release of DOX against MCF-7 breast cancer. The minimum CMC/PCL fiber diameter was found to be 300 nm by optimizing of three variables including voltage to distance ratio (1.5–2.5 kV/cm), CMC concentration (4−6 wt.%) and PCL concentration (8−12 wt.%). The synthesized core-shell fibers were characterized using FTIR, XRD, SEM, and TEM analysis. The extended release and controlled release of DOX from core-shell nanofibers were achieved under physiological pH without external magnetic field (EMF) and acidic pH with EMF during 25 and 7 days, respectively. The maximum cytotoxicity of MCF-7 breast cancer cells was about 83 % using CMC/PCL/nickel ferrite 10 % nanofibers and EMF.

由于通过壳层控制药物的释放曲线，已经开发了用于生产核-壳纳米纤维的同轴电纺丝。ñ通过同轴电纺丝制备了羧甲基壳聚糖（CMC）-聚乙烯醇（核）/聚（ε-己内酯）（PCL）（壳）纳米纤维。将阿霉素（DOX）和铁酸镍纳米颗粒掺入纳米纤维中，以控制DOX对抗MCF-7乳腺癌的释放。通过优化三个变量，包括电压与距离之比（1.5-2.5 kV / cm），CMC浓度（4-6 wt。％）和PCL浓度（8-12 wt％），发现最小CMC / PCL纤维直径为300 nm。 。％）。使用FTIR，XRD，SEM和TEM分析对合成的核-壳纤维进行表征。DOX从核-壳纳米纤维的缓释和控释分别在25天和7天无外部磁场（EMF）的酸性pH和带有EMF的酸性pH下实现。