In this issue of Cancer Cell, Wheeler et al. report that mechanisms of exceptional response to cancer treatment can be grouped into four broad categories: dysregulated intracellular signaling pathways, altered DNA damage response, tumor microenvironment or immune engagement, and alterations associated with a favorable prognosis.

中文翻译：

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特殊反应者研究的教训

在本期《癌细胞》中，Wheeler 等人。报告称，对癌症治疗的异常反应机制可分为四大类：细胞内信号通路失调、DNA 损伤反应改变、肿瘤微环境或免疫参与以及与良好预后相关的改变。