Abundant neoantigens are considered responsible for the immunotherapy sensitivity of mismatch repair-deficient (MMRd) cancers. In this issue of Cancer Cell, two papers show that MLH1 mismatch repair gene loss promotes cGAS-STING activation, interferon secretion, and T cell priming. This may be essential for the high immunotherapy sensitivity in MMRd cancer.

中文翻译：

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错配修复缺陷型癌症的免疫疗法敏感性：突变负荷不足

大量的新抗原被认为与错配修复缺陷型（MMRd）癌症的免疫治疗敏感性有关。在本期《癌细胞》中，有两篇论文表明MLH1错配修复基因的缺失会促进cGAS-STING激活，干扰素分泌和T细胞启动。这可能对MMRd癌症的高免疫疗法敏感性至关重要。