New condensed pyrimidine compounds with a benzoannelated quinazoline structure and various functional substituents at the pyrimidine N3-position were synthesized and included 2-methyl-3-(2-phenyl-2-oxoethyl) quinazolin-4(3 H )-one; 3-(2- tert -butyl-2-oxoethyl)quinazolin-4(3 H )-one; 3-[2-(1-naphthyl)-2-oxoethyl]-6-bromoquinazolin-4(3 H )-one; 3-(2-isopropyloxy-2-oxoethyl)quinazolin-4(3 H )-one; and 3-{2-[(4,6-dimethylpyrimidin- 2-yl)amino]-2-oxoethyl}quinazolin-4(3 H )-one. The new quinazoline derivatives were found to produce a corrective action on proliferation processes in immunocompetent organs as manifested by restoration of the number of splenocytes and thymocytes on the background of cyclophosphan-induced immunosuppression in CBA mice of both sexes aged 3 – 4 months.

中文翻译：

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新型喹唑啉衍生物的合成及其对小鼠的免疫活性

合成了新的缩合嘧啶化合物，该化合物具有苯并芳基喹唑啉结构和嘧啶 N3 位的各种功能性取代基，包括 2-甲基-3-(2-苯基-2-氧乙基)喹唑啉-4(3 H)-one；3-(2-叔丁基-2-氧乙基)喹唑啉-4(3H)-one；3-[2-(1-萘基)-2-氧乙基]-6-溴喹唑啉-4(3H)-one；3-(2-isopropyloxy-2-oxoethyl)quinazolin-4(3H)-one；和 3-{2-[(4,6-二甲基嘧啶-2-基)氨基]-2-氧乙基}喹唑啉-4(3H)-one。发现新的喹唑啉衍生物对免疫活性器官的增殖过程产生纠正作用，表现为在 3-4 个月大的两性 CBA 小鼠中，在环磷酰胺诱导的免疫抑制背景下，脾细胞和胸腺细胞的数量恢复。