Abstract

The reactions of 2,2-dichlorovinyl ketones with hydroxylamine hydrochloride give the corresponding oximes. The subsequent heterocyclization of the latter under the action of t-BuOK in t-BuOH results in selective formation of 5-chloro-3-alkyl- or 5-chloro-3-aryl-substituted isoxazoles in good yields.

中文翻译：

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2,2-二氯乙烯基酮衍生的5-氯代异恶唑的合成

摘要

2，2-二氯乙烯基酮与羟胺盐酸盐的反应得到相应的肟。后者随后在t- BuOH中在t- BuOK的作用下杂环化，导致以良好的产率选择性形成5-氯-3-烷基-或5-氯-3-芳基取代的异恶唑。